2-(2'-Chloro-biphenyl-2-yl)-acetamidine hydrochloride salt → 2-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:13][C:14]#[N:15])[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.ClC1C=CC=CC=1C1C=CC=CC=1CC(N)=[NH:32]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:13][C:14]([NH2:32])=[NH:15])[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1Participants
3
Procedure
2-[1-(4-chlorophenyl)-cyclopentyl]-acetamidine HCl salt (26-02) (6 g, 80.21%) was synthesized from [1-(4-chlorophenyl)-cyclopentyl]-acetonitrile (25-02) (6 g, 27.39 mmol) as a white gummy solid as a crude product following the procedure as described for 2-(2′-chloro-biphenyl-2-yl)-acetamidine hydrochloride salt (5-02).
Sources & evidence
- ORD record
- ord-a75133f08beb425bb7194f80599f2554
- Source dataset
- uspto-grants-2015_06
- DOI