1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile → 1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde
Reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([C:18]#N)[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.FC(F)(F)C1C=CC(C2(C=[O:36])CCCC2)=CC=1>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([CH:18]=[O:36])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1Participants
3
Procedure
1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde (456) was synthesized as a colourless liquid from 1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbonitrile (455) following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbaldehyde (238).
Sources & evidence
- ORD record
- ord-2a8cab4be8d94141a4c9b489cf2b80d3
- Source dataset
- uspto-grants-2015_06