1-(3-Chlorophenyl)cyclopentanecarbonitrile → 1-(3-Chlorophenyl)cyclopentanecarbaldehyde

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2([C:13]#N)[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.FC(F)(F)C1C=CC(C2(C=[O:29])CCCC2)=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2([CH:13]=[O:29])[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 157427191-(3-Chlorophenyl)cyclopentanecarbonitrile

HCID 218996431-(4-Trifluoromethyl-phenyl)-cyclopentanecarbaldehyde

Product 1

HCID 143821901-(3-Chlorophenyl)cyclopentanecarbaldehyde

Procedure

1-(3-Chlorophenyl)cyclopentanecarbaldehyde (495) was synthesized from 1-(3-chlorophenyl)cyclopentanecarbonitrile (494) following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbaldehyde (238).

Sources & evidence

ORD record: ord-59576081325045539da2fe03afa0b771
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09045486B2

Reaction notes

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