Suberic acid → Oxonane-2,9-dione
Reaction equation
[C:1]([OH:12])(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=O>CC(OC(C)=O)=O>[O:12]1[C:1](=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1=[O:10]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Under N2 atmosphere 50 g suberic acid and 100 ml acetanhydride were refluxed for 2 hours. The solvent was evaporated and 200 ml acetonitrile were added to the residue and the mixture was kept in a freezer over night. Then the mixture was fritted and the resulting residue was washed with 50 ml acetonitrile and dried.
Workup
- customThe solvent was evaporated
- addition200 ml acetonitrile were added to the residue
- waitthe mixture was kept in a freezer over night
- washthe resulting residue was washed with 50 ml acetonitrile
- customdried
Sources & evidence
- ORD record
- ord-d4634b1c94844c949baa8b06a896ae0b
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08193246B2
Reaction notes
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