2,4,6-Trichloropyrimidine → HCID 86728334, compound

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[CH3:10][NH:11][C@@H:12]([CH3:15])[CH2:13][OH:14]>>[Cl:1][C:2]1[N:3]=[C:4]([N:11]([CH3:10])[C@H:12]([CH3:15])[CH2:13][OH:14])[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

Reactant 2

HCID 773782,4,6-Trichloropyrimidine

HCID 12695786(2S)-2-(Methylamino)propan-1-ol

Product 1

HCID 86728334HCID 86728334, compound

Procedure

The title compound was prepared by a procedure similar to that described for D27 starting from 2,4,6-trichloropyrimidine and (S)-2-(methylamino)propan-1-ol.

Sources & evidence

ORD record: ord-f94498467ae1451cbfb99e2b24ac341a
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051325B2

Reaction notes

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