HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2171985Generated: October 26, 2026
Sodium hydride → 1-(Diphenylmethyl)-3-(2-thienylmethoxy)azetidine
https://huagongshe.com/reaction/2171985
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| Reactant | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Diphenylmethyl)-3-(2-thienylmethoxy)azetidine | HCID 67154602 | — |
Reaction Steps
To a solution of 1-diphenylmethylazetidin-3-ol (359 mg, 1.5 mmol) in DMF (1 mL) at 0° C. under nitrogen was added NaH (60% in oil, 66 mg, 1.65 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with 2-(chloromethyl)thiophene (464 mg, 3.5 mmol; which may be prepared as described in Step 1) dissolved in DMF (2 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09051321B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-2727df192e7b4ea0bfd48e78ab5e4410 |
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| Source note | uspto-grants-2015_06 |
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