4,6-Dichloro-2-methylpyrimidine → 6-chloro-N-((2,4-dimethylthiazol-5-yl)methyl)-2-methylpyrimidin-4-amine

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][C:11]1[S:12][C:13]([CH2:17][NH2:18])=[C:14]([CH3:16])[N:15]=1>>[Cl:8][C:6]1[N:5]=[C:4]([CH3:9])[N:3]=[C:2]([NH:18][CH2:17][C:13]2[S:12][C:11]([CH3:10])=[N:15][C:14]=2[CH3:16])[CH:7]=1

Participants

Reactant 2

HCID 2349974,6-Dichloro-2-methylpyrimidine

HCID 25219195(Dimethyl-1,3-thiazol-5-yl)methanamine

Product 1

HCID 867295676-chloro-N-((2,4-dimethylthiazol-5-yl)methyl)-2-methylpyrimidin-4-amine

Procedure

The title compound was prepared from 4,6-dichloro-2-methylpyrimidine and (2,4-dimethylthiazol-5-yl)methanamine according to the protocol outlined in Example 1, to afford 3A-1 as a solid. LRMS (ES) (M+H)+: observed=269.1, calculated=269.7.

Workup

customto afford 3A-1 as a solid

Sources & evidence

ORD record: ord-ccba840ce6df437aa8be4a2dc119943d
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062059B2

Reaction notes

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