Cyanomethylenetributylphosphorane → (9aR)-tert-butyl 3-(2-chloro-3-cyano-4-fluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate
Reaction equation
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([F:10])[CH:5]=[CH:4][C:3]=1[CH:11](O)[CH2:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][C@@H:14]1[CH2:26][OH:27].C(C=P(CCCC)(CCCC)CCCC)#N>C1C=CC=CC=1>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([F:10])[CH:5]=[CH:4][C:3]=1[CH:11]1[O:27][CH2:26][C@H:14]2[CH2:15][N:16]([C:19]([O:21][C:22]([CH3:24])([CH3:25])[CH3:23])=[O:20])[CH2:17][CH2:18][N:13]2[CH2:12]1Participants
4
Conditions
- Temperature
- 100 °C