1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester → 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole

HRID 2176627Notes

Reaction equation

HRID 2176627 reaction equation
C(N1C=C([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)C=N1)C.Br[C:18]1[CH:19]=[N:20][N:21]([CH2:23][C:24]([F:27])([F:26])[F:25])[CH:22]=1>>[CH3:15][C:10]1([CH3:16])[C:11]([CH3:14])([CH3:13])[O:12][B:8]([C:18]2[CH:19]=[N:20][N:21]([CH2:23][C:24]([F:27])([F:26])[F:25])[CH:22]=2)[O:9]1

Participants

3

Reactant 2

HCID 113790451-Ethyl-1H-pyrazole-4-boronic acid, pinacol esterHCID 610302834-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole

Product 1

HCID 689235864-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole

Procedure

The title compound was prepared in the same manner as 1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole starting with 4-bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole.

Sources & evidence

ORD record
ord-2cd2c9622f9246078e2dd5247c84dc4b
Source dataset
uspto-grants-2015_06
Patent number
US09066954B2

Reaction notes

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