Ammonia → HCID 21973937, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9](OCC)=[O:10])=[CH:3][CH:2]=1.[NH3:15]>>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9]([NH2:15])=[O:10])=[CH:3][CH:2]=1Participants
3
Procedure
A solution of ethyl 3-(pyridin-4-yl)butanoate (0.50 g, 2.59 mmol) in methanolic ammonia (10 ml) was heated to 100° C. in a pressure bomb for 48 h. The solvent was evaporated under reduced pressure to afford the crude compound, which was washed with n-pentane and dried under reduced pressure to afford 0.2 g (47%) of 3-(pyridin-4-yl)butanamide as an off-white solid.
Workup
- customThe solvent was evaporated under reduced pressure
- customto afford the crude compound, which
- washwas washed with n-pentane
- customdried under reduced pressure
Sources & evidence
- ORD record
- ord-bae163c026e14c37a50e9d65809f4649
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09067888B2
Reaction notes
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