Ethyl 3-(2,6-difluoro-4-hydroxyphenyl)propanoate → 3-(3,5-Difluoro-4-((4-(4-methoxyphenyl)-2-(trifluoromethyl)thiophen-3-yl)methoxy)phenyl)propanoic acid

Reaction equation

CS(OCC1C(C2C=CC(OC)=CC=2)=CSC=1C(F)(F)F)(=O)=O.FC1C=C(O)C=C(F)C=1CCC(OCC)=O.[F:40][C:41]1[CH:42]=[C:43]([CH2:67][CH2:68][C:69]([O:71]CC)=[O:70])[CH:44]=[C:45]([F:66])[C:46]=1[O:47][CH2:48][C:49]1[C:53]([C:54]2[CH:59]=[CH:58][C:57]([O:60][CH3:61])=[CH:56][CH:55]=2)=[CH:52][S:51][C:50]=1[C:62]([F:65])([F:64])[F:63]>>[F:40][C:41]1[CH:42]=[C:43]([CH2:67][CH2:68][C:69]([OH:71])=[O:70])[CH:44]=[C:45]([F:66])[C:46]=1[O:47][CH2:48][C:49]1[C:53]([C:54]2[CH:59]=[CH:58][C:57]([O:60][CH3:61])=[CH:56][CH:55]=2)=[CH:52][S:51][C:50]=1[C:62]([F:64])([F:65])[F:63]