Sodium Hydroxide → 2-Isopropyl-4-trifluoromethyl-benzoic acid

Reaction equation

C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1I.[Br-].[CH3:17][CH:18]([Zn+])[CH3:19].[OH-].[Na+]>>[CH:18]([C:5]1[CH:6]=[C:7]([C:10]([F:13])([F:12])[F:11])[CH:8]=[CH:9][C:4]=1[C:3]([OH:2])=[O:15])([CH3:19])[CH3:17]

Participants

Reactant 3

HCID 14798Sodium Hydroxide

HCID 59438424Methyl 2-iodo-4-(trifluoromethyl)benzoate

HCID 178461827HCID 178461827, compound

Product 1

HCID 594385402-Isopropyl-4-trifluoromethyl-benzoic acid

Procedure

In analogy to the procedure described for the synthesis of example B.10, the title compound was prepared from 2-iodo-4-trifluoromethyl-benzoic acid methyl ester and 2-propyl zinc bromide followed by saponification with sodium hydroxide. MS (m/e): 231.0 (M−H)