2-Bromo-5-fluoropyridine → 1-(5-Fluoro-2-pyrimidinyl)-1H-imidazo[4,5-c]pyridine

Reaction equation

[F:1][C:2]1[CH:3]=C[C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[N:10]=[CH:9]2)=[N:6][CH:7]=1.BrC1C=CC(F)=C[N:19]=1>>[F:1][C:2]1[CH:7]=[N:6][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[N:10]=[CH:9]2)=[N:19][CH:3]=1

Participants

Reactant 2

HCID 27831712-Bromo-5-fluoropyridine

HCID 904095831-(5-Fluoropyridin-2-yl)-1H-imidazo[4,5-c]pyridine

Product 1

HCID 904100971-(5-Fluoro-2-pyrimidinyl)-1H-imidazo[4,5-c]pyridine

Procedure

Intermediate 6 was prepared in a manner analogous to Intermediate 1, substituting 2-bromo-5-fluoropyrimidine for 2-bromo-5-fluoropyridine. MS (ESI): mass calculated for C10H6FN5, 215.06. m/z found 216.1 [M+H]+.

Sources & evidence

ORD record: ord-f4a21eef991d4d6cb1ba8c20bbb31b05
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09066946B2

Reaction notes

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