2-Bromo-5-fluoropyridine → 1-(4-Fluorophenyl)-1H-imidazo[4,5-c]pyridine

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[N:10]=[CH:9]2)=N[CH:7]=1.Br[C:18]1C=CC(F)=CN=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[N:10]=[CH:9]2)=[CH:18][CH:7]=1

Participants

Reactant 2

HCID 27831712-Bromo-5-fluoropyridine

HCID 904095831-(5-Fluoropyridin-2-yl)-1H-imidazo[4,5-c]pyridine

Product 1

HCID 904093891-(4-Fluorophenyl)-1H-imidazo[4,5-c]pyridine

Procedure

Intermediate 7 was prepared in a manner analogous to Intermediate 1, substituting 1-bromo-4-fluorobenzene for 2-bromo-5-fluoropyridine. MS (ESI): mass calculated for C12H8FN3, 213.07; m/z found 214.1 [M+H]+.

Sources & evidence

ORD record: ord-e28adbf60bd24c7e8528b49cdc509e5c
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09066946B2

Reaction notes

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