(1R)-3-chloro-1-phenylpropan-1-ol → 4-Bromo-2-[[(1R)-3-chloro-1-phenylpropyl]oxy]-5-fluorobenzonitrile
Reaction equation
[Br:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[Cl:12][CH2:13][CH2:14][C@H:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:16]>>[Br:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:16][C@@H:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:14][CH2:13][Cl:12])[CH:3]=1Participants
3
Procedure
This was prepared by the method of Example 43(a) using 4-bromo-2,5-difluorobenzonitrile and (R)-α-(2-chloroethyl)benzenemethanol.
Workup
- customThis was prepared by the method of Example 43(a)
Sources & evidence
- ORD record
- ord-d1a0036c030b4ac980b1c9d0ee1a4416
- Source dataset
- uspto-grants-2005_05
- Patent number
- US06887871B2
Reaction notes
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