Hydrazine → 3-(1-Methylpiperazin-2-YL)propan-1-amine
Reaction equation
[NH2:1]N.[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12]C1C=CC=C2C(NC(=O)C=12)=O>CO>[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12][NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Hydrazine (aqueous solution at 35% by wt.) (0.15 ml; 1.6 mmoles) was added to 3-(N-methylpiperazinyl)propylphthalimide (229 mg; 0.8 mmoles) in methanol (5 ml) and the resulting solution was refluxed. Reaction times and process as per Example 1.
Workup
- temperaturethe resulting solution was refluxed
- customReaction times and process as per Example 1
Sources & evidence
- ORD record
- ord-c6c1e1d9583c4a30b639ec091611be7a
- Source dataset
- uspto-grants-1995_06
- Patent number
- US05424451
Reaction notes
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