Acetylcholine → Acetylcholine Serotonin

HRID 218240

Reaction equation

[C:1]([O:4][CH2:5][CH2:6][N+:7]([CH3:10])([CH3:9])[CH3:8])(=[O:3])[CH3:2].[CH:11]1[C:16]([OH:17])=[CH:15][C:14]2[C:18]([CH2:21][CH2:22][NH2:23])=[CH:19][NH:20][C:13]=2[CH:12]=1>>[C:1]([O:4][CH2:5][CH2:6][N+:7]([CH3:10])([CH3:9])[CH3:8])(=[O:3])[CH3:2].[CH:11]1[C:16]([OH:17])=[CH:15][C:14]2[C:18]([CH2:21][CH2:22][NH2:23])=[CH:19][NH:20][C:13]=2[CH:12]=1

Participants

Reactant 2

HCID 187Acetylcholine

HCID 5202Serotonin

Product 1

HCID 18539443Acetylcholine Serotonin

Procedure

Microdialysis studies (resting or challenging conditions) in freely moving, male Sprague Dawley rats (Janvier, 295-315 g, n=5-8/treatment group) were performed using stereotactically instrumented microdialysis probes (CMA/12-14-2): mPFC, hippocampus. Aliquots of the same microdialysate fractions (6 before, and 9-12 after compound administration) were analyzed either for acetylcholine or for serotonin by HPLC and electrochemical detection.

Sources & evidence

ORD record: ord-65c9d0e14e114f47a07e1f45f656d75b
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08198331B2

Linked notes

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