HCID 18782313, compound → HCID 22458120, compound
Reaction equation
[CH:1]1([C:7]([N:9]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][C:34]([F:37])([F:36])[F:35])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[O:25][CH3:26])[CH2:14][CH2:13]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.NC1C=CC=CC=1N(C(C1CCCCC1)=O)CCN1CCN([C:54]2C=CC=C[C:55]=2[O:60]C)CC1>>[CH:1]1([C:7]([N:9]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][C:34]([F:36])([F:37])[F:35])[CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:55](=[O:60])[CH3:54])=[CH:20][C:19]=3[O:25][CH3:26])[CH2:16][CH2:17]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
3
Procedure
The title compound was synthesized according to the procedure reported in example 28 but substituting the compound of example 56 for the compound of example 27 and stirring for 20 h. The residue was purified by flash chromatography (CHCl3-2 N methanolic NH3 100:3) affording the title compound as a vitreous pink solid. Yield: 77%.
Workup
- customThe title compound was synthesized
- customThe residue was purified by flash chromatography (CHCl3-2 N methanolic NH3 100:3)