6-(Propan-2-yl)pyridin-3-amine → 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

HRID 218551Notes

Reaction equation

HRID 218551 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:20](O)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:25]=[CH:26][C:27]([CH:30]([CH3:32])[CH3:31])=[N:28][CH:29]=1>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:20]([NH:23][C:24]1[CH:29]=[N:28][C:27]([CH:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=1)=[O:21])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 178542886-(Propan-2-yl)pyridin-3-amineHCID 178545405-Benzyloxy-8-fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Product 1

HCID 178541605-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideYield 88.6%

Procedure

By the reaction and treatment in the same manner as in Preparation Example 11 using 5-benzyloxy-8-fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (2.30 g) and 5-amino-2-isopropylpyridine (1.04 g) as starting materials, 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (2.83 g) was obtained. melting point: 184.0° C.

Workup

  1. customBy the reaction and treatment in the same manner

Sources & evidence

ORD record
ord-be84fb88189349caa9992b3dcbf58368
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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