methyl 5-methyl-2,3-dihydro-1H-indole-2-carboxylate → HCID 85707549, compound
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]([C:11]([O:13]C)=O)[CH2:5]2>C(N)CCC>[CH2:6]([NH:7][C:11]([CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:2]([CH3:1])[CH:3]=2)[NH:7]1)=[O:13])[CH2:5][CH2:4][CH3:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Methyl 5-methylindoline-2(R/S)-carboxylate (0.3 g, 4.18 mmol) was dissolved in butylamine (20 ml) and the mixture was refluxed for 4 h under nitrogen. The excess amine was removed under vacuum to give a solid, which was recrystallized from ether in order to allow the product to be collected.
Workup
- temperaturethe mixture was refluxed for 4 h under nitrogen
- customThe excess amine was removed under vacuum
- customto give a solid, which
- customwas recrystallized from ether in order
- customto be collected
Sources & evidence
- ORD record
- ord-239c0ba8916541089e8bd93385a52246
- Source dataset
- uspto-grants-2002_06
- Patent number
- US06403561B1
Reaction notes
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