Methanol → methyl (2S)-2,3-dihydro-1H-indole-2-carboxylate
Reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[C:10]([OH:12])=[O:11].[CH3:13]O>S(=O)(=O)(O)O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[C:10]([O:12][CH3:13])=[O:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Indoline-2(S)-carboxylic acid (10 g, 64 mmol) was refluxed in a mixture of methanol (50 ml) and sulphuric acid (8 ml) for 5 h. The solvent was removed to give the product in the form of an oil.
Workup
- customThe solvent was removed
- customto give the product in the form of an oil
Sources & evidence
- ORD record
- ord-e67c410ff18343e7a8bb2b621cca852e
- Source dataset
- uspto-grants-2002_06
- Patent number
- US06403561B1
Reaction notes
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