Trifluoroacetic acid methylene chloride → 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinohydrazide hydrochloride
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:26]=[N:25][CH:24]=[CH:23][C:11]=1[C:12]([NH:14][NH:15]C(OC(C)(C)C)=O)=[O:13].C(O)(C(F)(F)F)=O.C(Cl)[Cl:35]>>[ClH:35].[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:26]=[N:25][CH:24]=[CH:23][C:11]=1[C:12]([NH:14][NH2:15])=[O:13]Participants
3
Procedure
3-[(2-fluoro-4-iodophenyl)amino]isonicotinohydrazide hydrochloride was synthesized from tert-butyl 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}hydrazine-carboxylate (described earlier) by deprotection of the Boc group under acidic conditions (50:50 TFA/DCM). LC/MS [7.11 min; 373 (free base, M+1)]
Workup
- customLC/MS [7.11 min; 373 (free base, M+1)]