Benzenecarbothioic acid, 2,5-difluoro-, hydrazide → HCID 86639138, compound
Reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:3]=1[C:4](=[S:7])[NH:5][NH2:6].[CH3:13][O:14][N:15]([CH2:23][CH2:24][C:25](=O)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19]>C(O)C>[F:1][C:2]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:3]=1[C:4]1[S:7][C:25]([CH2:24][CH2:23][N:15]([O:14][CH3:13])[C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:21])[CH3:19])([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[NH:6][N:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2,5-difluorobenzothiohydrazide (0.500 g 2.66 mmol) and tert-butyl methoxy(3-oxo-3-phenylpropyl)carbamate (1.11 g, 3.99 mmol) was stirred together in ethanol (5 mL) for 30 hours. The reaction mixture was concentrated under reduced pressure, and the residue was chromatographed (20% ethyl acetate in hexanes) to provide die product (0.650 g, 1.45 mmol) that was used in the next step without further purification.