2,2-Dimethylsuccinic anhydride → 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-2,2-dimethyl-4-oxo-butyric acid

HRID 2190649

Reaction equation

HRID 2190649 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:7][C:6](=[O:8])[O:5][C:3]1=[O:4].[C:10]([C:14]1[CH:15]=[C:16]([NH:20][C:21](=[O:34])[C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[CH:24][CH:23]=2)[CH:17]=[CH:18][CH:19]=1)([CH3:13])([CH3:12])[CH3:11]>>[C:10]([C:14]1[CH:15]=[C:16]([NH:20][C:21]([C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH2:33][CH2:32][N:31]([C:6](=[O:8])[CH2:7][C:2]([CH3:9])([CH3:1])[C:3]([OH:5])=[O:4])[CH2:30][CH2:29]3)=[CH:24][CH:23]=2)=[O:34])[CH:17]=[CH:18][CH:19]=1)([CH3:13])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 870672,2-Dimethylsuccinic anhydrideHCID 59318141N-(3-tert-Butyl-phenyl)-4-piperazin-1-yl-benzamide

Product 1

HCID 593180284-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-2,2-dimethyl-4-oxo-butyric acid

Procedure

4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-2,2-dimethyl-4-oxo-butyric acid was prepared from 2,2-dimethylsuccinic anhydride and N-(3-tert-butyl-phenyl)-4-piperazin-1-yl-benzamide. HRMS m/z calcd for C27H35N3O4 [M+H]+: 466.2701. Found: 466.2698.

Sources & evidence

ORD record
ord-21b33d04b261442dbb65e77c49a6ce32
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Linked notes

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