CID 6037 → HCID 178484386, compound

HRID 2191896Notes

Reaction equation

HRID 2191896 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[CH:10]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:14][CH:13]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:11]=1>C(O)C>[CH:14]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:10][CH:11]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:13]=1.[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3]

Participants

4

Reactant 2

HCID 6037CID 6037HCID 178484382HCID 178484382, compound2×

Product 1

HCID 178484386HCID 178484386, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Procedure

Under nitrogen gas, 150 mL fresh ethanol was added to the free base of metformin in ethanol, and to the free base of metformin in ethanol was slowly added 42 g (0.095 eq.) folacin solid. At that time the temperature of the reaction mixture began to ascend. The reaction was stirred and the adding speed was controlled to keep the reaction temperature not exceeding 50° C. Stirring was continued until the solid was substantially dissolved. When new solid began to present, ⅔-⅘ volume of solvent was removed under reduced pressure, and the reaction was cooled to ambient temperature to give the crude product of folacin-metformin compound.

Workup

  1. customexceeding 50° C
  2. stirringStirring
  3. dissolutionwas substantially dissolved
  4. custom⅔-⅘ volume of solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ea37497c9b484071a21980134ca89a4a
Source dataset
uspto-grants-2012_12
Patent number
US08329710B2

Reaction notes

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