5-Methyl-1,2-oxazole-4-sulfonyl chloride → 8-(5-Methyl-isoxazole-4-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194166

Reaction equation

HRID 2194166 reaction equation
C(O)(=O)C.[F:5][C:6]([F:26])([F:25])[O:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][CH2:17][C:16]3([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:15]2=[O:24])=[CH:10][CH:9]=1.[CH3:27][C:28]1[O:32][N:31]=[CH:30][C:29]=1[S:33](Cl)(=[O:35])=[O:34]>>[CH3:27][C:28]1[O:32][N:31]=[CH:30][C:29]=1[S:33]([N:21]1[CH2:20][CH2:19][C:16]2([C:15](=[O:24])[N:14]([C:11]3[CH:12]=[CH:13][C:8]([O:7][C:6]([F:5])([F:25])[F:26])=[CH:9][CH:10]=3)[CH2:18][CH2:17]2)[CH2:23][CH2:22]1)(=[O:35])=[O:34]

Participants

3

Reactant 2

HCID 27761415-Methyl-1,2-oxazole-4-sulfonyl chlorideHCID 667873332-(4-Trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt

Product 1

HCID 595779998-(5-Methyl-isoxazole-4-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 180 step D from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt (described in example 180 step C) and 5-methyl-isoxazole-4-sulfonyl chloride. White solid. MS (ESI): 460.3 (MH+).

Sources & evidence

ORD record
ord-21f3c9c489fa44ccbe734e4bf4ca2459
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Linked notes

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