Benzoic acid, 2-(chlorosulfonyl)-3-methyl-, methyl ester → HCID 59578055, compound
Reaction equation
C(O)(=O)C.[F:5][C:6]([F:26])([F:25])[O:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][CH2:17][C:16]3([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:15]2=[O:24])=[CH:10][CH:9]=1.[CH3:27][O:28][C:29](=[O:41])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[C:31]=1[S:37](Cl)(=[O:39])=[O:38]>>[CH3:27][O:28][C:29](=[O:41])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[C:31]=1[S:37]([N:21]1[CH2:20][CH2:19][C:16]2([C:15](=[O:24])[N:14]([C:11]3[CH:12]=[CH:13][C:8]([O:7][C:6]([F:5])([F:25])[F:26])=[CH:9][CH:10]=3)[CH2:18][CH2:17]2)[CH2:23][CH2:22]1)(=[O:38])=[O:39]Participants
3
Procedure
The title compound was prepared in analogy to example 180 step D from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt (described in example 180 step C) and 2-Chlorosulfonyl-3-methyl-benzoic acid methyl ester. White solid. MS (ESI): 527.14 (MH+)
Sources & evidence
- ORD record
- ord-f59520a7de8a4385b668ccd6110d0dad
- Source dataset
- uspto-grants-2012_12