(Chlorothio)formyl chloride → HCID 67079379, compound
Reaction equation
Cl[C:2]([S:4]Cl)=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15]([NH2:17])=[O:16])=[CH:9][CH:8]=1>C1(C)C=CC=CC=1>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][C:15]2[O:16][C:2](=[O:3])[S:4][N:17]=2)=[CH:11][CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
11.60 g (88.5 mmol) of chlorocarbonylsulphenyl chloride and 13.54 g (73.8 mmol) of 3-(4-chlorophenyl)propionamide are stirred in 25 ml of toluene at 70° C. for 3 h. Subsequently, the mixture is cooled and freed from a solvent under vacuum and the residue is purified by column chromatography. 15.6 g of product are obtained (99.9% purity, 87.6% yield, log P (pH 2.3)=3.36).
Workup
- temperatureSubsequently, the mixture is cooled
- customthe residue is purified by column chromatography
Sources & evidence
- ORD record
- ord-d61bb4d7079244b18137299bc7eb4301
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08334235B2
Reaction notes
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