2-Allyloxy-6-chloro-pyrazine → 2-Allyloxy-6-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-pyrazine

HRID 2194404

Reaction equation

HRID 2194404 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:19][C:20]1[CH:25]=[N:24][CH:23]=[C:22](Cl)[N:21]=1)[CH:17]=[CH2:18]>>[CH2:16]([O:19][C:20]1[CH:25]=[N:24][CH:23]=[C:22]([N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:11]=[C:12]2[CH3:15])[N:21]=1)[CH:17]=[CH2:18]

Participants

3

Reactant 2

HCID 136828392-Allyloxy-6-chloro-pyrazineHCID 178432693HCID 178432693, compound

Product 1

HCID 668656112-Allyloxy-6-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-pyrazine

Procedure

The title compound, white cristalline solid, MS: m/e=351.2, 353.2 (M+H+), was prepared in accordance with the general method of example 1b from 4-(3-chloro-phenylethynyl)-2-methyl-1H-imidazole and 2-Allyloxy-6-chloro-pyrazine (CAS: [107466-49-9].

Sources & evidence

ORD record
ord-de8647e942404083a6177309f7a43f31
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Linked notes

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