Sulfuric Acid → Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](Cl)Cl.OS(O)(=O)=O>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH3:17])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid 51 was added 80 mL of CH2Cl2, 30 mL of MeOH, and 1.0 mL of concentrated H2SO4. After heating at reflux overnight, the mixture concentrated and triturated with water to give methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate 52.
Workup
- temperatureAfter heating
- temperatureat reflux overnight
- concentrationthe mixture concentrated
- customtriturated with water
Sources & evidence
- ORD record
- ord-2cc664b3ae924667a33cba9c70007ba2
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08334317B2
Reaction notes
Loading…