(R)-3-Methylmorpholine → 4-[4-(4-Fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-pyrimidin-2-yl]-3-methyl-morpholine

HRID 2195073

Reaction equation

HRID 2195073 reaction equation
[CH3:1][C@@H:2]1[CH2:7][O:6][CH2:5][CH2:4][NH:3]1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH:22]3[CH3:27])[N:18]=[C:17](N3CCCC3C)[N:16]=2)=[CH:11][CH:10]=1>>[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH:22]3[CH3:27])[N:18]=[C:17]([N:3]3[CH2:4][CH2:5][O:6][CH2:7][CH:2]3[CH3:1])[N:16]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 641498(R)-3-MethylmorpholineHCID 668388634-(4-Fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

Product 1

HCID 668388934-[4-(4-Fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-pyrimidin-2-yl]-3-methyl-morpholine

Procedure

This compound is prepared using (R)-3-methylmorpholine (WO 02/064096) in a procedure analogous to that used for the preparation of 4-(4-fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine in Example 2F step 3.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-fae9a48770a249c1a684c396150a1411
Source dataset
uspto-grants-2012_12
Patent number
US08334382B2

Linked notes

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