Ammonia → HCID 67499901, compound

Reaction equation

[F:1][C:2]1[C:3]([C:8]2([F:18])[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.ClC1C(C2(F)CCC3(OCCO3)CC2)=NC=CC=1.N>>[F:18][C:8]1([C:3]2[C:2]([F:1])=[CH:7][CH:6]=[CH:5][N:4]=2)[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]1

Participants

Reactant 3

HCID 222Ammonia

HCID 67499172HCID 67499172, compound

HCID 67499484HCID 67499484, compound

Product 1

HCID 67499901HCID 67499901, compound

Procedure

The title compound was prepared using the procedure as described in Example 1C, except for substituting the product of Example 15B for the product of Example 1B. 1H NMR (300 MHz, DMSO-d6) δ 8.41 (m, 1H), 7.80 (m, 1H), 7.56 (m, 1H), 2.80-2.22 (m, 8H). MS (DCI/NH3) m/e 212 (M+H)+.

Sources & evidence

ORD record: ord-5f09db94d58c492494814995fc1ad39b
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338603B2

Reaction notes

Loading…