Thionyl Chloride → N-(4-Dipropylaminobutyl)-3-methyl-N-propyl-2-(8-trifluoromethyl-4-quinolylamino)benzamide
Reaction equation
Cl.[CH3:2][C:3]1[C:4]([NH:12][C:13]2[C:22]3[C:17](=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15][CH:14]=2)=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].ClC1C2C(=C(C(F)(F)F)C=CC=2)N=CC=1.NC1C(C)=CC=CC=1C(O)=O.S(Cl)(Cl)=O.[CH2:57]([N:60]([CH2:69][CH2:70][CH3:71])[CH2:61][CH2:62][CH2:63][CH2:64][NH:65][CH2:66][CH2:67][CH3:68])[CH2:58][CH3:59]>>[CH2:69]([N:60]([CH2:57][CH2:58][CH3:59])[CH2:61][CH2:62][CH2:63][CH2:64][N:65]([CH2:66][CH2:67][CH3:68])[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([CH3:2])[C:4]=1[NH:12][C:13]1[C:22]2[C:17](=[C:18]([C:23]([F:26])([F:24])[F:25])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1)[CH2:70][CH3:71]Participants
6
Reactant 5
Product 1
Procedure
3-Methyl-2-(8-trifluoromethyl-4-quinolylamino)benzoyl chloride hydrochloride prepared by the reaction of 4-chloro-8-trifluoromethylquinoline with 2-amino-3-methylbenzoic acid and treatment of the reaction product with thionyl chloride, is reacted with 1-dipropylamino-4-propylaminobutane to afford the title compound.
Sources & evidence
- ORD record
- ord-0f1a37954e8e4436a0cc07408d0619cc
- Source dataset
- uspto-grants-1982_11
- Patent number
- US04357333
Reaction notes
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