M-Cresol → HCID 4728832, compound

Reaction equation

[CH:1]([N:5]1[CH2:8][CH:7]([OH:9])[CH2:6]1)([CH2:3][CH3:4])[CH3:2].[CH:10]1[C:15]([OH:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17]>>[CH3:17][C:11]1[CH:10]=[C:15]([CH:14]=[CH:13][CH:12]=1)[O:16][CH2:6][CH:7]([OH:9])[CH2:8][NH:5][CH:1]([CH2:3][CH3:4])[CH3:2]

Participants

Reactant 2

HCID 342M-Cresol

HCID 205173831-(1-Methylpropyl)-3-azetidinol

Product 1

HCID 4728832HCID 4728832, compound

Procedure

1-(sec.-butyl)-3-azetidinol and m-cresol were reacted in the same manner as in Example 6 to yield 1-(3-methylphenoxy)-3-(sec.-butylamino)-2-propanol. A hydrochloric acid gas was blown to yield 1-(3-methylphenoxy)-3-(sec.-butylamino)-2-propanol hydrochloride melting at 159°-160° C. The yield was 69%.

Sources & evidence

ORD record: ord-8b51c67f675644f2a89e336350a1b474
Source dataset: uspto-grants-1982_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04360464

Reaction notes

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