HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Benzoic acid, 4-fluoro-, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Product | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
Reaction Steps
A mixture containing 35 g of 4-fluorobenzoyl chloride in 50 ml of 100% ethanol is refluxed for 15 minutes. 35 g of the ethyl 4-fluorobenzoate obtained are mixed with 22 g of imidazole and 61 g of potassium carbonate in 35 ml of DMSO. The mixture is heated for 18 hours at 120°-130° C. and 500 ml of iced water are then added. A precipitate forms and the expected product crystallizes from iso ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728723 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-43d95d9c07ef43d581eb72b8af369b67 |
| Source note | uspto-grants-1998_03 |