Formaldehyde → HCID 13066913, compound

Reaction equation

[CH3:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1.[CH2:15]=[O:16]>>[OH:16][CH2:15][C:5]1[C:6](=[O:8])[NH:7][C:2]([CH3:1])=[C:3]([C:9]2[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=2)[CH:4]=1

Participants

Reactant 2

HCID 712Formaldehyde

HCID 1333512-methyl-3,4'-bipyridin-6(1H)-one

Product 1

HCID 13066913HCID 13066913, compound

Procedure

In another process aspect the invention comprises reacting 6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone with excess formaldehyde at an acidic pH to produce 3-hydroxymethyl-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone.

Sources & evidence

ORD record: ord-ea3ff20e634d4bfda8cf25331bfca2a5
Source dataset: uspto-grants-1982_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04361569

Reaction notes

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