3,5-Diamino-2-methylbenzoic acid → Methyl 2-(3-(methylamino)propyl)-1H-benzo[d]imidazole-5-carboxylate

HRID 220248

Reaction equation

HRID 220248 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH2:11])[CH:5]=1.CO[C:15]1C(OC)=C[C:18]2[NH:19][C:20](CCCNC)=N[C:17]=2[CH:16]=1>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[CH:8][C:7]2[NH:10][C:15]([CH2:16][CH2:17][CH2:18][NH:19][CH3:20])=[N:11][C:6]=2[CH:5]=1)=[O:12]

Participants

3

Reactant 2

HCID 1355243,5-Diamino-2-methylbenzoic acidHCID 61363740[3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine

Product 1

HCID 178483380Methyl 2-(3-(methylamino)propyl)-1H-benzo[d]imidazole-5-carboxylate

Procedure

Prepared from 3,4-diamino-benzoic acid methyl ester (Eur. J. Med. Chem. 2004, 39(3), 291-298) in analogy to the methods described for [3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.

Sources & evidence

ORD record
ord-ed0ebb2e04f9409d9ff17be88a6e3980
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Linked notes

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