[2-(2-Amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester → HCID 178488952, compound

HRID 220251

Reaction equation

HRID 220251 reaction equation
[C:1]([O:5][C:6](=[O:23])[N:7]([CH2:9][CH2:10][C:11](=O)[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[C:14]=1[NH2:21])[CH3:8])([CH3:4])([CH3:3])[CH3:2]>C(O)(=O)C>[C:1]([O:5][C:6](=[O:23])[N:7]([CH2:9][CH2:10][C:11]1[NH:21][C:14]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 68411798[2-(2-Amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester

Product 1

HCID 178488952HCID 178488952, compoundYield 75.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2.1 g of crude [2-(2-amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL acetic acid was heated at 65° C. for 2 h. The reaction mixture was concentrated and purified by CC with EtOAc to yield 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester as orange foam.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by CC with EtOAc

Sources & evidence

ORD record
ord-2221cab70cb74afabc02b086ed5cf267
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Linked notes

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