Thionyl Chloride → HCID 21162562, compound
Reaction equation
O[CH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[Cl:15][CH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of ethyl 5-hydroxymethylthiophene-2-carboxylate synthesized in Production Example 72 in toluene, 212 μL of thionyl chloride was dropwise added, and the mixture was refluxed for 30 minutes. The mixture was allowed to cool down to a room temperature and stirred for one hour. After the completion of the reaction was confirmed by TLC, the solvent was distilled off. The resulting residue was used for the next reaction without purification.
Workup
- temperaturethe mixture was refluxed for 30 minutes
- distillationthe solvent was distilled off
- customThe resulting residue was used for the next reaction without purification
Sources & evidence
- ORD record
- ord-d1b09b591fe8417999c4ba3269e53045
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365553B2
Reaction notes
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