(2-Amino-3-chlorophenyl)amine → [3-(4-chloro-1H-benzoimidazol-2-yl)-propyl]methyl-amine

HRID 220279

Reaction equation

HRID 220279 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH2:9].CO[C:12]1C(OC)=C[C:15]2[NH:16][C:17](CCCNC)=N[C:14]=2[CH:13]=1>>[Cl:1][C:2]1[C:3]2[N:9]=[C:12]([CH2:13][CH2:14][CH2:15][NH:16][CH3:17])[NH:8][C:4]=2[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 3462489(2-Amino-3-chlorophenyl)amineHCID 61363740[3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine

Product 1

HCID 60787078[3-(4-chloro-1H-benzoimidazol-2-yl)-propyl]methyl-amine

Procedure

Prepared from 3-chloro-benzene-1,2-diamine (J. Med. Chem. 1981, 24(1), 93-101) in analogy to the methods described for [3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.

Sources & evidence

ORD record
ord-dec6873fbdc3443387e4eb4f4ad289b8
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Linked notes

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