HCID 66878002, compound → HCID 68415577, compound
Reaction equation
[OH:1][C:2]1([CH2:16][C:17](O)=O)[CH2:7][CH:6]2[CH2:8][CH2:9][CH:3]1[CH:4]=[C:5]2[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Cl:20][C:21]1[C:34]([Cl:35])=[CH:33][C:24]2[NH:25][C:26]([CH2:28][CH2:29][CH2:30][NH:31][CH3:32])=[N:27][C:23]=2[CH:22]=1>>[Cl:35][C:34]1[C:21]([Cl:20])=[CH:22][C:23]2[NH:27][C:26]([CH2:28][CH2:29][CH2:30][N:31]([CH3:32])[CH2:17][CH2:16][C:2]3([OH:1])[CH2:7][CH:6]4[CH2:8][CH2:9][CH:3]3[CH:4]=[C:5]4[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:25][C:24]=2[CH:33]=1Participants
3
Procedure
Prepared according to procedures P2.2 to P2.3 in Example 21 using rac-(1R*,2R*,4R*)-(2-hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-acetic acid and [3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-e6e2670133bb4c1f9d508e342a982acf
- Source dataset
- uspto-grants-2012_06