Sodium borohydride → 2-Thiazolemethanol, 4-(difluoromethyl)-
Reaction equation
[F:1][CH:2]([F:13])[C:3]1[N:4]=[C:5]([C:8](OCC)=[O:9])[S:6][CH:7]=1.[BH4-].[Na+]>CO>[F:1][CH:2]([F:13])[C:3]1[N:4]=[C:5]([CH2:8][OH:9])[S:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of ethyl 4-(difluoromethyl)-1,3-thiazole-2-carboxylate (900 mg) in MeOH (15 ml) was added NaBH4 (329 mg), and the mixture was stirred at room temperature for 2 h. The mixture was partitioned between saturated NH4Cl solution and EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo to give the title compound (703 mg) as a colorless oil.
Workup
- customThe mixture was partitioned between saturated NH4Cl solution and EtOAc
- washThe organic layer was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-cbb5073800864f14a8eaed68c6c1d4f9
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365540B2
Reaction notes
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