4-(benzyloxy)-1-(1,2-dimethyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one → 1-(1,2-Dimethyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one
Reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:22]=[C:21]([CH3:23])[N:20]([CH3:24])[C:19]=3[CH:25]=2)[C:11](=[O:26])[CH:10]=1)C1C=CC=CC=1>[Pd].CO>[CH3:24][N:20]1[C:19]2[CH:25]=[C:15]([N:12]3[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]3=[O:26])[CH:16]=[CH:17][C:18]=2[N:22]=[C:21]1[CH3:23]Participants
4
Procedure
A mixture of 4-(benzyloxy)-1-(1,2-dimethyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (627 mg), 10% Pd/C (193 mg) and MeOH (10 ml) was stirred under H2 atmosphere at room temperature for 1 h. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound (421 mg) as white crystals.