Pentane, 3-(chloromethyl)- → HCID 118257627, compound

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Br:14])[CH:8]=[C:9]2[C:13]=1[NH:12][N:11]=[CH:10]2)=[O:4].Cl[CH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Br:14])[CH:8]=[C:9]2[C:13]=1[N:12]([CH2:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])[N:11]=[CH:10]2)=[O:4]

Participants

Reactant 2

HCID 107585Pentane, 3-(chloromethyl)-

HCID 24728927Methyl 5-bromo-1H-indazole-7-carboxylate

Product 1

HCID 118257627HCID 118257627, compoundYield 22%

Procedure

Compound 15 was prepared following general method 1, using 5-bromo-1H-indazole-7-carboxylic acid methyl ester as a starting material and 3-chloromethyl-pentane as alkylating agent. Yield: 22%.

Sources & evidence

ORD record: ord-13a4384c782c4a9fb1144d65b99f66d6
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09365569B2

Reaction notes

Loading…