HCID 178474492, compound → 4-(2-phenylethynyl)-3-(trifluoromethyl)-1H-pyrazol-5-amine
Reaction equation
[C:1]1([C:7]#[C:8][C:9]2[C:10]([C:18]([F:21])([F:20])[F:19])=[N:11][NH:12][C:13]=2[NH:14]C(=O)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[OH-].[Na+]>[C:1]1([C:7]#[C:8][C:9]2[C:10]([C:18]([F:20])([F:21])[F:19])=[N:11][NH:12][C:13]=2[NH2:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of N-[4-(2-phenylethynyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetamide (900 mg, 3.07 mmol) in ethanol (12 mL) and 25% NaOH (9 mL) was heated to 70° C. for 1.5 h. The organic layer was separated and the aqueous extracted with EtOAc (×2).
Workup
- customThe organic layer was separated
- extractionthe aqueous extracted with EtOAc (×2)
Sources & evidence
- ORD record
- ord-2741886eac964a27b80037250bd38512
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09371332B2
Reaction notes
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