Hydrogen chloride-ethyl acetate → Oxan-4-ylhydrazine dihydrochloride

HRID 2205996Notes

Reaction equation

HRID 2205996 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([NH:7][NH:8]C(OC(C)(C)C)=O)[CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[O:1]1[CH2:6][CH2:5][CH:4]([NH:7][NH2:8])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 45092245N'-(oxan-4-yl)(tert-butoxy)carbohydrazide

Product 1

HCID 50988431Oxan-4-ylhydrazine dihydrochloride

Procedure

tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate (1.82 g) was dissolved in 4N hydrogen chloride-ethyl acetate solution (85 mL) under ice-cooling, and the solution was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure to give the title compound (1.52 g).

Workup

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e0bf9401af274c7fb0f43c5a4cd2ab76
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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