HCID 10703244, compound → HCID 12915443, compound
Reaction equation
[CH:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2)=[CH2:2]>[Pd].CO>[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Methyl 2-vinyl-1H-indole-3-carboxylate (80 mg, 0.4 mmol) and 10% palladium on charcoal (100 mg) in methanol (30 mL) were stirred under hydrogen 0.2 MPa at room temperature for 15 hours. The mixture was filterated the solid and concentrated in vacuum to obtain methyl 2-ethyl-1H-indole-3-carboxylate as a white solid (79 mg, 99%) LRMS (M+H+) m/z: calcd 203.1 found 203.
Workup
- concentrationconcentrated in vacuum
Sources & evidence
- ORD record
- ord-203afddc55f74a9c9c0a0bcc1443ef45
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09371331B2
Reaction notes
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