Thionyl Chloride → HCID 19035209, compound

Reaction equation

[F:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[C:9]([F:15])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>>[F:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[C:9]([F:15])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:18])=[O:5]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 97945292,4-difluoro-3-(trifluoromethyl)benzoic Acid

Product 1

HCID 19035209HCID 19035209, compound

Conditions

Temperature: 50 °C

Procedure

19.3 g (0.085 mol) of 2,4-difluoro-3-trifluoromethylbenzoic acid are added in portions at room temperature to 130 ml of thionyl chloride. After metering has ended, the mixture is heated at 50° C. until the evolution of gas has ceased. The excess thionyl chloride is then removed by distillation and the crude product is reacted further directly.

Workup

customThe excess thionyl chloride is then removed by distillation
customthe crude product is reacted further directly

Sources & evidence

ORD record: ord-2f5d5cf8c6624651ad1aacee2d8e1d7a
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05457104

Reaction notes

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