HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxyphenylacetone → N-[2-(4-Hydroxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethylthiazol-4-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxyphenylacetone | HCID 7019274 | — |
| Reactant | 4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- | HCID 14076239 | — |
| Product | N-[2-(4-Hydroxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethylthiazol-4-yl)ethanamine | HCID 19974300 | — |
Reaction Steps
Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 4-hydroxyphenyl-propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol =9:1 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457205 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-5e65596097724e07a828efa4585deca1 |
| Source note | uspto-grants-1995_10 |