5-Methylbenzo(b)thiophene → 5-Bromo-2-chloro-1-(5-methylbenzo[b]thiophen-2-ylmethyl)benzene

HRID 221076

Reaction equation

HRID 221076 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.[Br:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:20])=[C:16]([CH:19]=1)[CH:17]=O>>[Br:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:20])=[C:16]([CH2:17][C:7]2[S:6][C:5]3[CH:9]=[CH:10][C:2]([CH3:1])=[CH:3][C:4]=3[CH:8]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 843465-Methylbenzo(b)thiopheneHCID 106089255-Bromo-2-chlorobenzaldehyde

Product 1

HCID 666088075-Bromo-2-chloro-1-(5-methylbenzo[b]thiophen-2-ylmethyl)benzene

Procedure

5-Methylbenzo[b]thiophene and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 7 to give the target compound.

Workup

  1. additionwere treated in a manner similar to Reference Example 7
  2. customto give the target compound

Sources & evidence

ORD record
ord-0476b0ad28f2459a8640f9349c855d89
Source dataset
uspto-grants-2012_06
Patent number
US08202984B2

Linked notes

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